To add an IP to 127.0.0.1:
route add 192.16.1.100 gw 127.0.0.1 lo
Also it can be rejected by:
route add -host 192.168.1.100 reject
Block entire subnet 192.168.1.0/24:
route add -net 192.168.1.0/24 gw 127.0.0.1 lo
To delete this rule:
route del -host 192.168.1.100 reject