Navigate to Status → System Logs → System → DNS Resolver.
Many log message showing errors such as:
Mar 26 13:21:16 unbound 33572:0 notice: sendto failed: Permission denied
NOTE: The resolver settings are not dynamically checking/applying upstream ipv4/6 connectivity but assuming both are active.
Simply ignore for these messages for now, or allow IPv6 on the WAN.
Usually due to ET DNS Query to a *.pw domain - Likely Hostile.
In the past Unbound could crash with a buffer overflow.
But this should have been fixed.